Publications

Diagnostic utility of plasma translocator protein 18 kDa (TSPO) in sepsis: A case–control study
jats:pTranslocator protein 18 kDa (TSPO) is a mitochondrial membrane protein that is involved in inflammation, oxidative stress, and …
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Cholinergic modulation of interhemispheric inhibition in the mouse motor cortex
Interhemispheric inhibition of the homotopic motor cortex is believed to be effective for accurate unilateral motor function. However, …
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Nutritional Imbalance between Omega-6 and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Increases the Number of Pyramidal Neurons in the Basolateral Amygdala and Anxiety-Related Behavior in Offspring
Modern agriculture allows for the production of foods that are high in n-6 linoleic acid and low in n-3 α-linolenic acid …
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Neural mechanisms underlying uninstructed orofacial movements during reward-based learning behaviors
During reward-based learning tasks, animals make orofacial movements that globally influence brain activity at the timings of reward …
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Deep ultraviolet fluorescence microscopy of three-dimensional structures in the mouse brain
Three-dimensional (3D) imaging at cellular resolution improves our understanding of the brain architecture and is crucial for …
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Genetic deletion of translocator protein exacerbates post-sepsis syndrome with activation of the C1q pathway in septic mouse model
ABSTRACT: Significant numbers of patients who survive sepsis exhibit psychiatric and cognitive impairments, termed post-sepsis …
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Electrophysiological and pharmacological characterization of spreading depolarization in the adult zebrafish tectum
Spreading depolarization (SD) is a slowly propagating wave of neuronal and glial depolarization. A growing number of studies show that …
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Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants are used to manage and treat epilepsy in Malawi because of traditional beliefs and …
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A novel microcontroller-based system for the wheel-running activity in mice
Voluntary wheel-running activity is a way to assess rodents' circadian rhythm and motivation for exercise. Deficits in these behaviors …
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Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine
Animals suffering from uncontrollable stress sometimes show low effort to escape stress (learned helplessness). Changes in serotonin …
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Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model
ABSTRACT: Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction associated with sepsis. The development of an effective …
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Glial glutamate transporter GLT-1 determines susceptibility to spreading depression in the mouse cerebral cortex
Cortical spreading depression (CSD) is a pathological neural excitation that underlies migraine pathophysiology. Since glutamate …
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Microglial translocator protein and stressor-related disorder
Despite the prevalence of neuroinflammation in psychiatric disorders, molecular mechanism underlying it remains elusive. Translocator …
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Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix
The lateral habenula (LHb) attracts a growing interest as a regulator of monoaminergic activity which were frequently reported to be …
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Dopaminergic signaling in the nucleus accumbens modulates stress-coping strategies during inescapable stress
Maladaptation to stress is a critical risk factor in stress-related disorders, such as major depression and post-traumatic stress …
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Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study
Human habenula studies are gradually advancing, primarily through the use of functional magnetic resonance imaging (fMRI) analysis of …
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Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress
In preclinical models, it has been reported that social defeat stress activates microglial cells in the CNS. Translocator protein 18 …
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Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice
Peripheral lipopolysaccharide (LPS) injection induces systemic inflammation through the activation of the inhibitor of nuclear factor …
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Toward an understanding of the habenula's various roles in human depression
The habenula is an evolutionarily conserved structure in the vertebrate brain. Lesion and electrophysiological studies in animals have …
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Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice
Glial glutamate transporter GLT1 plays a key role in the maintenance of extracellular glutamate homeostasis. Recent human genetic …
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Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice
Patients with major depressive disorder have elevated peripheral inflammation; the degree of this increase correlates with the severity …
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Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice
Alternative splicing (AS) that occurs at the final coding exon (exon 47) of the Cav2.1 voltage-gated calcium channel (VGCC) gene …
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Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ
BACKGROUND: Although CRISPR/Cas enables one-step gene cassette knock-in, assembling targeting vectors containing long homology arms is …
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Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice
Point mutations in the vacuolar protein sorting 35 gene (VPS35) have been associated with an autosomal dominant form of late-onset …
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Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits
Neuronal heterotopia refers to brain malformations resulting from deficits of neuronal migration. Individuals with heterotopias show a …
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Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice
An increase in the ratio of cellular excitation to inhibition (E/I ratio) has been proposed to underlie the pathogenesis of …
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The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger
Anticipation of danger at first elicits panic in animals, but later it helps them to avoid the real threat adaptively. In zebrafish, as …
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Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance
The lateral habenula (LHb) regulates the activity of monoaminergic neurons in the brainstem. This area has recently attracted a surge …
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Hyperactivation of the habenula as a link between depression and sleep disturbance
Depression occurs frequently with sleep disturbance such as insomnia. Sleep in depression is associated with disinhibition of the rapid …
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Reward-modulated motor information in identified striatum neurons
It is widely accepted that dorsal striatum neurons participate in either the direct pathway (expressing dopamine D1 receptors) or the …
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Imaging of neural ensemble for the retrieval of a learned behavioral program
The encoding of long-term associative memories for learned behaviors is a fundamental brain function. Yet, how behavior is stably …
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The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation
Lateral habenula (LHb) has attracted growing interest as a regulator of serotonergic and dopaminergic neurons in the CNS. However, it …
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Fear and anxiety regulation by conserved affective circuits
In this issue of Neuron, Yamaguchi et al. (2013) demonstrated that inactivation of two parallel neural pathways connecting the …
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Habenula and the asymmetric development of the vertebrate brain
Habenula is a relay nucleus connecting the forebrain with the brain stem and plays a pivotal role in cognitive behaviors by regulating …
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Molecular characterization of the subnuclei in rat habenula
The mammalian habenula is involved in regulating the activities of serotonergic and dopaminergic neurons. It consists of the medial and …
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Phylogeny and ontogeny of the habenular structure
Habenula is an epithalamic nucleus connecting the forebrain with the ventral midbrain and hindbrain that plays a pivotal role in …
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The habenula is crucial for experience-dependent modification of fear responses in zebrafish
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is …
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Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula
The mammalian habenula consists of the medial and lateral habenulae. Recent behavioral and electrophysiological studies suggested that …
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Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements
Motor cortex neurons are activated at different times during self-initiated voluntary movement. However, the manner in which excitatory …
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Development of the mouse amygdala as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation
The amygdala is located in the caudal part of the ventral telencephalon. It is composed of many subdivisions and is involved in the …
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Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish
The vertebrate brain is innately equipped with neural circuits that make quick behavioral decisions possible. Elucidating these neural …
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Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafish
The optic tectum is a visual center in vertebrates. It receives topographically ordered visual inputs from the retina in the …
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Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems
The dorsal hindbrain includes distinct classes of neurons for processing various sensory stimuli, but the developmental aspects of …
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Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures
The habenular neurons on both sides of the zebrafish diencephalon show an asymmetric (laterotopic) axonal projection pattern into the …
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Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus
The habenulae are part of an evolutionarily highly conserved limbic-system conduction pathway that connects telencephalic nuclei to the …
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Development of the amygdalohypothalamic projection in the mouse embryonic forebrain
The amygdalohypothalamic projection, a major component of the stria terminalis, is involved in the conduction of emotional and …
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Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
We have accumulated information of the coding sequences of uncharacterized human genes, which are known as KIAA genes, and the number …
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Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice
Recent studies have implicated presenilin-1 (PS-1) in the processing of the amyloid precursor protein and Notch-1. We show that PS-1 …
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