Title: In vivo brain ischemia-reperfusion model induced by hypoxia-reoxygenation using zebrafish larvae
Journal: Brain Research Bulletin (2021) 173: 45-52
Link: https://www.sciencedirect.com/science/article/pii/S0361923021001349
Comments:
The study describes the development of a novel model of cerebral ischemia in larval zebrafish. Embedded larvae exposed to hypoxic medium displayed interrupted cerebral and dorsal aorta blood flow. Hypoxia-reoxygenation (H/R) treatment induced cerebral ischemia-reperfusion, followed by neuronal death and gliosis. This ischemia model, once fully established, may be used in the study stroke and other related pathologies.
Mayeso Naomi Gwedela
Lecturer
Ms. Gwedela comes from Malawi and is interested in medicinal herbs for the treatment of epileptic patients.